Initial examination will call for getting the ball out quickly, on flat or drag routes -- often in some "mesh" configuration. Some forms of offensive thinking will depend solely on quick routes versus this defensive structure. Superior match-ups may allow for this, but the defense can counter vs. a limited arsenal, and pounce when they see a familiar pattern. The big hit on Demarius Thomas was proof of this:
The premise remains: in attacking man coverage, explosive plays are a must, and are not always available when solely releasing the ball in quick rhythm.